A model study of the effects of calcium conductance on the stability of cardiac reentrant activity

Author

Awada, A.H. ; Leon, L.Joshua

Author_Institution

Inst. de Genie Biomed., Montreal Univ., Que., Canada

Volume

2

fYear

1999

fDate

36434

Abstract

A two-dimensional sheet model of cardiac tissue was used to study the effects of changes in calcium channel conductance on the stability of reentrant activity. The sheet is modeled as a set of parallel, continuous and uniform cables transversely interconnected by a brick-wall arrangement of fixed resistors. Reentrant activity was induced using a cross-stimulation protocol. The reentry observed in sheets in which the calcium channel conductance was reduced exhibited a more stable reentrant rhythm

Keywords

bioelectric phenomena; biomembrane transport; calcium; cardiology; physiological models; Ca; brick-wall arrangement; calcium channel conductance; cardiac electrophysiology; cardiac reentrant activity stability; fixed resistors; more stable reentrant rhythm; parallel continuous uniform cables; transverse interconnection; Blood; Cables; Calcium; Cardiac tissue; Fibrillation; North America; Protocols; Resistors; Rhythm; Stability;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.804353

Filename

804353