Title :
A genetically-engineered polypeptide carrier for thermal targeting of therapeutics
Author :
Meyer, Dan E. ; Kong, Garheng ; Dewhirst, Mark ; Chilkoti, Ashutosh
Author_Institution :
Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
Abstract :
Reports the synthesis of a environmentally-responsive polypeptide carrier for thermally-targeted delivery of radionuclide therapeutics. The authors hypothesized that systemically-injected radionuclide-polypeptide conjugates are likely to be cleared from circulation under physiological conditions, while externally-induced local hyperthermia at tumor sites will result in radionuclide accumulation because of carrier aggregation. The authors report preliminary in vivo results which support this hypothesis
Keywords :
genetics; hyperthermia; radiation therapy; radioisotopes; tumours; carrier aggregation; externally-induced local hyperthermia; genetically-engineered polypeptide carrier; physiological conditions; preliminary in vivo results; radionuclide therapeutics; systemically-injected radionuclide-polypeptide conjugates; thermal targeting; tumor sites; Biological information theory; Chemistry; Encoding; Medical treatment; Neoplasms; Polymers; Proteins;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.804458
