An implantable high-voltage cortical stimulator for post-stroke rehabilitation enhancement with high-current driving capacity

This paper presents a high-voltage, high-current implantable cortical stimulation integrated circuit aiming at supporting the rehabilitation of patients suffering from stroke. In this context, a large area of the motor cortex needs to be stimulated, requiring high current densities at the electrode-electrolyte interface. The designed integrated circuit contains eight fully programmable stimulation channels generating biphasic constant current pulses up to 8mA from a 20V supply. The current mismatch between positive and negative pulses has been evaluated at 0.03%. The chip has been fabricated in an AMS 0.18μm high-voltage CMOS process, and has a die area of 5mm².