In vivo-activation of photodynamic hematoporphyrin-derivative (HPD) by HIFU

Author

Spoo, J. ; Jenne, J. ; Jochle, K. ; Huber, Patrik ; Lorenz, W.J. ; Wannenmacher, M. ; Debus, Jurgen

Author_Institution

Dept. of Radiotherapy, Heidelberg Univ., Germany

Volume

2

fYear

1997

fDate

5-8 Oct 1997

Firstpage

1341

Abstract

The object of the authors´ investigations is the in vivo-activation of photosensitizing agents by high energy ultrasound (HIFU) in order to minimize side effects and to increase penetration depth of photodynamic treatments. Animal experiments were carried out using the Dunning rat prostrate adenocarcinoma R3327-AT1 in Copenhagen rats. Macroscopic treatment response was evaluated and biologically graded. The authors were able to assess a synergistic tissue interaction of HIFU (f=1.18 MHz, I=3530 W/cm²) and hematoporphyrin-derivative

Keywords

biological tissues; biomedical ultrasonics; organic compounds; photodynamic therapy; 1.18 MHz; Copenhagen rats; Dunning rat prostrate adenocarcinoma R3327-AT1; high energy ultrasound; in vivo-activation; macroscopic treatment response; penetration depth increase; photodynamic hematoporphyrin-derivative; side effects minimization; synergistic tissue interaction; Animals; Cancer; Hyperthermia; Medical treatment; Neoplasms; Piezoelectric transducers; Rats; Thigh; Ultrasonic imaging; Ultrasonic variables measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 1997. Proceedings., 1997 IEEE

Conference_Location

Toronto, Ont.

ISSN

1051-0117

Print_ISBN

0-7803-4153-8

Type

conf

DOI

10.1109/ULTSYM.1997.661824

Filename

661824