Title :
Notice of Retraction
ABCC8 and Type 2 Diabetes: A Global Meta-Analysis
Author :
Yi Lv ; Lulu Cui ; Dehwah, M.A.S. ; Meng Gao ; Jie Wen ; Qingyang Huang
Author_Institution :
Hubei Key Lab. of Genetic Regul. & Integrative Biol., Central China Normal Univ., Wuhan, China
Abstract :
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
ABCC8 was widely studied for association with type 2 diabetes in various ethnic groups; however, contradictory results have been reported. We performed a comprehensive meta-analysis of 23 studies for rs1799854, 7 studies for rsl801261, 4 studies for rs4148643 and 7 studies for rs757110 variants of the ABCC8 gene to evaluate the effect of the ABCC8 gene on genetic susceptibility for type 2 diabetes. Meta-analysis revealed a significant association of rs757110 with type 2 diabetes with a combined allelic OR of 1.135 (95%CI 1.053-1.224, P=0.001), whereas rs1799854, rs1801261, rs4148643, which showed a low linkage disequilibrium with rs757110, were not associated with type 2 diabetes worldwide.
Keywords :
diseases; medical computing; statistical analysis; ABCC8 diabetes; allelic OR; genetic susceptibility; global meta analysis; rs4148643; rs757110; rsl799854; rsl801261; type 2 diabetes; Couplings; Data models; Databases; Diabetes; Encoding; Genetics; Insulin;
Conference_Titel :
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location :
Wuhan
Print_ISBN :
978-1-4244-5088-6
DOI :
10.1109/icbbe.2011.5780007
