Effect of high intensity focused ultrasound on intracellular signaling in rat liver

Author

Zaitsev, A.V. ; Sanghvi, N.T. ; Jin, N. ; Hatton, N.B. ; Rhoades, R.A.

Author_Institution

ICFAR, Indiana Univ., Indianapolis, IN, USA

Volume

2

fYear

1997

fDate

5-8 Oct 1997

Firstpage

1371

Abstract

High Intensity Focused Ultrasound (HIFU) can be used as a minimal invasive therapeutic modality for ablating diseased tissue. The objective of the present investigation was to determine the effect of of HIFU treatment on adjacent tissue of the treatment zone (i.e., tissue in the near field of the HIFU beam). Activity of mitogen activated protein (MAP) kinase and protein kinase C (PKC), and expression of early response gene (c-jun) were chosen to investigate changes in intracellular signalling in rat liver following HIFU treatment

Keywords

biological effects of acoustic radiation; biomedical ultrasonics; cellular effects of radiation; liver; ultrasonic effects; c-jun; diseased tissue ablation; early response gene expression; high intensity focused ultrasound effect; intracellular signaling; minimal invasive therapeutic modality; mitogen activated protein kinase activity; protein kinase C; rat liver; tissue adjacent to treatment zone; Animals; Biochemistry; Biological materials; Biomembranes; Liver; Probes; Proteins; Radio access networks; Surgery; Ultrasonic imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 1997. Proceedings., 1997 IEEE

Conference_Location

Toronto, Ont.

ISSN

1051-0117

Print_ISBN

0-7803-4153-8

Type

conf

DOI

10.1109/ULTSYM.1997.661831

Filename

661831