Notice of RetractionComputational Modeling of the Antithrombotic Antibody SZ2 in Complex with Glycoprotein Ibalpha

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

Binding of platelet glycoprotein Ibα (GPIbα) to von Willebrand factor (vWF) is closely related to the process of physiological hemostasis and pathological thrombosis. Monoclonal antithrombotic antibody SZ2 can inhibit ristocetin induced platelet agglutination and thrombin-induced platelet aggregation via binding to the anionic region of GPIbα. To investigate the interaction between SZ2 and GPIbα at the residue level, here we perform a computational modeling via homology modeling, molecular docking and intermolecular interactions analysis. Proper conformations of SZ2 and SZ2/GPIbα complex are presented; the key residues in SZ2 and GPIbα are also identified, which are consistent with known experimental evidence. Our study may provide novel insights into SZ2 modification and antibody research, especially in lacking of both crystal structures and mutagenesis data.