DocumentCode
3318132
Title
Notice of Retraction
Computational Modeling of the Antithrombotic Antibody SZ2 in Complex with Glycoprotein Ibalpha
Author
Xiang Fang ; Ying Fang ; Jianhua Wu
Author_Institution
Sch. of Biosci. & Eng., South China Univ. of Technol., Guangzhou, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
4
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Binding of platelet glycoprotein Ibα (GPIbα) to von Willebrand factor (vWF) is closely related to the process of physiological hemostasis and pathological thrombosis. Monoclonal antithrombotic antibody SZ2 can inhibit ristocetin induced platelet agglutination and thrombin-induced platelet aggregation via binding to the anionic region of GPIbα. To investigate the interaction between SZ2 and GPIbα at the residue level, here we perform a computational modeling via homology modeling, molecular docking and intermolecular interactions analysis. Proper conformations of SZ2 and SZ2/GPIbα complex are presented; the key residues in SZ2 and GPIbα are also identified, which are consistent with known experimental evidence. Our study may provide novel insights into SZ2 modification and antibody research, especially in lacking of both crystal structures and mutagenesis data.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Binding of platelet glycoprotein Ibα (GPIbα) to von Willebrand factor (vWF) is closely related to the process of physiological hemostasis and pathological thrombosis. Monoclonal antithrombotic antibody SZ2 can inhibit ristocetin induced platelet agglutination and thrombin-induced platelet aggregation via binding to the anionic region of GPIbα. To investigate the interaction between SZ2 and GPIbα at the residue level, here we perform a computational modeling via homology modeling, molecular docking and intermolecular interactions analysis. Proper conformations of SZ2 and SZ2/GPIbα complex are presented; the key residues in SZ2 and GPIbα are also identified, which are consistent with known experimental evidence. Our study may provide novel insights into SZ2 modification and antibody research, especially in lacking of both crystal structures and mutagenesis data.
Keywords
bioinformatics; blood; drugs; medical computing; proteins; anionic region; computational modeling; crystal structure; homology modeling; intermolecular interactions analysis; molecular docking; monoclonal antithrombotic antibody SZ2; mutagenesis data; pathological thrombosis; physiological hemostasis; platelet agglutination; platelet glycoprotein Ibα; thrombin nduced platelet aggregation; von Willebrand factor; Amino acids; Analytical models; Blood; Computational modeling; Crystals; Immune system; Proteins;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5780046
Filename
5780046
Link To Document