DocumentCode
3318631
Title
Notice of Retraction
Effects of Estradiol on Amyloid Beta and Tau Protein Positive Neurons at Hippocampal CA1 Area of Ovariectomized Dementia Rats
Author
Jun Zhao ; Jane Yuxia Qin ; Zhao Heng
Author_Institution
Bio-Sci. & Tech. Coll., ChangChun Univ., Changchun, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
4
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
To observe the changes of amyloid beta peptide and tau protein positive of hippocampus in ovariectomized rats of Alzheimer´s disease and the effect of estrogen. The model of the AD and ovariectomized(AD+OVX) rats was established by transecting hippocampal fimbria-fornix and OVX of rats. We used Morris water maze to test the changes of cognitive function in each group. We detected the changes of amyloid beta peptide and tau protein positive of hippocampus in ovariectomized rats of Alzheimer´s disease by immunocytochemistry. The ability of learning and memory were increased significantly and the expression of amyloid beta peptide and tau protein positive of hippocampus in ovariectomized rats of Alzheimer´s disease, while amyloid beta peptide and tau protein positive of hippocampus in AD-OVX rats was decreased. EB could improve the ability of learning and memory by decreasing the level of Aβand tau protein positive of hippocampus.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
To observe the changes of amyloid beta peptide and tau protein positive of hippocampus in ovariectomized rats of Alzheimer´s disease and the effect of estrogen. The model of the AD and ovariectomized(AD+OVX) rats was established by transecting hippocampal fimbria-fornix and OVX of rats. We used Morris water maze to test the changes of cognitive function in each group. We detected the changes of amyloid beta peptide and tau protein positive of hippocampus in ovariectomized rats of Alzheimer´s disease by immunocytochemistry. The ability of learning and memory were increased significantly and the expression of amyloid beta peptide and tau protein positive of hippocampus in ovariectomized rats of Alzheimer´s disease, while amyloid beta peptide and tau protein positive of hippocampus in AD-OVX rats was decreased. EB could improve the ability of learning and memory by decreasing the level of Aβand tau protein positive of hippocampus.
Keywords
biochemistry; cellular biophysics; cognition; diseases; molecular biophysics; molecular configurations; neurophysiology; proteins; AD-OVX rats; Alzheimer disease; Morris water maze; amyloid beta peptide; cognitive function; estradiol effects; estrogen; hippocampal CA1 area; immunocytochemistry; learning; memory; ovariectomized dementia rats; positive neurons; tau protein; transecting hippocampal fimbria-fornix; Alzheimer´s disease; Neurons; Peptides; Proteins; Rats;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5780082
Filename
5780082
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