DocumentCode
3318839
Title
Notice of Retraction
Chromatin Organization in Different Types of Splicing Events
Author
Huan Huang ; Shuangxin Yu ; Hongde Liu ; Xiao Sun
Author_Institution
State Key Lab. of Bioelectronics, Southeast Univ., Nanjing, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
4
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Recent studies have demonstrated that pre-mRNA splicing is initiated during gene transcription. The cross-talk between chromatin organization and mRNA splicing has also been analyzed. But it is not clear whether chromatin organization is related with different types of splicing events. We previously investigated the length distribution of exons and flanking introns, nucleosome occupancy and histone modification in different types of splicing exons. Our data suggests that short exons with short flanking introns have a tendency to be more frequently retained as constitutive exons. Nucleosome positioning around exon is more likely to improve exons inclusion and splicing efficiency. Different histone modifications were also found in constitutive and alternative exons, suggesting a special role in alternative splicing.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Recent studies have demonstrated that pre-mRNA splicing is initiated during gene transcription. The cross-talk between chromatin organization and mRNA splicing has also been analyzed. But it is not clear whether chromatin organization is related with different types of splicing events. We previously investigated the length distribution of exons and flanking introns, nucleosome occupancy and histone modification in different types of splicing exons. Our data suggests that short exons with short flanking introns have a tendency to be more frequently retained as constitutive exons. Nucleosome positioning around exon is more likely to improve exons inclusion and splicing efficiency. Different histone modifications were also found in constitutive and alternative exons, suggesting a special role in alternative splicing.
Keywords
DNA; bioinformatics; crosstalk; molecular biophysics; molecular configurations; proteins; chromatin organization; crosstalk; exons; gene transcription; histone modification; introns; length distribution; nucleosome occupancy; nucleosome positioning; pre-mRNA splicing; splicing events; Bioinformatics; DNA; Genomics; Humans; Organizations; RNA; Splicing;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5780097
Filename
5780097
Link To Document