Notice of RetractionPreliminary Purification of Salsolinol Synthase from Rat Brain

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

Several studies suggest that 1-methyl-6, 7-dihydroxy-1, 2, 3, 4 tetrahydroisoquinoline (Salsolinol, Sal) is toxic to dopaminergic neurons, and it is one of the most discussed tetrahydroisoquinolines whose chemical structure is the same with MPTP, it may cause PD. Studies show that salsolinol is biosynthesized by a novel enzyme named salsolinol synthase in human brain. Salsolinol synthase is one kind of enzyme catalyzes the condensation of dopamine and acetaldehyde. It was preliminary purified from rat brains first time in this paper. The purification procedure involved ultracentrifugation, DEAE anion exchange chromatography and gel filtration chromatography. HPLC-ECD was used for enzyme activity detection during purification. Salsolinol synthase was purified 2753.1 fold from the crude enzyme extract.