Simulation of Nerve Conduction Block Induced by High Frequency Sinus/Square Biphasic Electrical Current and Suggested Novel Electrical Current (Assimilating High Frequency Sinus/Square Pulses) Based on Schwarz-Reid-Bostock Model

Nerve conduction block has been simulated by high frequency sinusoidal, square pulses and a new suggested waveform (assimilating sinusoidal and square electrical pulses), using a Lamped circuit model of the myelinated axons based on Schwartz equations. In this simulation the diameter of nerve fibers, has been selected between (1-20 μm) and has used (1-6 kHz) frequency range. At higher frequencies, higher stimulation intensity is needed to block nerve conduction. Larger diameter axons have lower block thresholds. Such high frequencies can be used for long periods because of lower needed currents and resulted lower nerves and electrode damages. K⁺ channels activation is dominant mechanism for high frequency blocking, compared with Na⁺ channels deactivation. The goal is selective stimulation, using high-frequency current, can be blocked the large fibers successfully and can be found a reasonable stimulation range, with lower amplitude for small diameter nerve fibers. This study is a try for high frequency electrical nerve blocking as a start for future studies on animal models (in vivo).