Title :
Analytical Solution of Gene Regulatory Networks
Author_Institution :
Imperial Coll. London, London
Abstract :
We study gene regulatory networks that include the effect of multiple binary interactions, when various genes can activate or inhibit other genes, as well as of ternary interactions where two genes jointly affect the level of activity of a third gene. We also prove that Boolean identities for the activation state of a gene in terms of the activation level of another set of genes, can be represented, so that the overall probability of activation of any gene in the network can be computed in the presence of logical dependencies, and excitatory-inhibitory interactions between genes.
Keywords :
genetic engineering; genetics; probability; Boolean identities; activation probability; excitatory-inhibitory interactions; gene regulatory networks; logical dependencies; multiple binary interactions; Biological information theory; Biological system modeling; Biology computing; Cells (biology); Computer networks; Continuous time systems; Negative feedback loops; Organisms; Proteins; Time factors;
Conference_Titel :
Fuzzy Systems Conference, 2007. FUZZ-IEEE 2007. IEEE International
Conference_Location :
London
Print_ISBN :
1-4244-1209-9
Electronic_ISBN :
1098-7584
DOI :
10.1109/FUZZY.2007.4295674