Bioelectronic Nose Based on Olfactory Sensory Neural Networks by Microelectrode Array Culture

Olfaction guides many significant behaviors for creatures so that study on olfactory transduction mechanism is being attended. In the present paper, we present a novel bioelectronic nose with microelectrode array, whose sensing element is the in vitro olfactory sensory neural networks by culture. Using this electronic nose, we observed the spontaneous signals of OSNs as well as the induced response to Acetic acid. Under the action of Acetic acid, the firing rate of neurons increased distinctively. Moreover, at different site of OSNs networks, OSNs appeared different firing pattern. The bioelectronic nose based on OSNs with MEA provided multi scale olfactory information and show electrophysiological characteristics at different position, which is favorable for further modeling the olfactory neuronal networks.