DocumentCode
3322908
Title
Notice of Retraction
An Alternative Sustained Release Microsphere of Silk Fibroin-Chitosan: Preparation, Pharmaceutical Characteristics and Pharmacokinetic Profiles
Author
Ying Hu ; Chun Liu ; Yang Liu ; Meng-yao Jin ; Xue-nong Zhang
Author_Institution
Coll. of Pharm. Sci., Soochow Univ., Suzhou, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
4
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
The silk fibroin-chitosan loaded diclofenac sodium microspheres (DS-SF/CS-MS) were prepared with an emulsion crosslinking technique. The loading drug content and encapsulated efficiency of the obtained microspheres were (9.88±0.49)% and (50.35±0.92)%, respectively, with the average diameter was about (26.54±1.39)μm. The release profile of DS-SF/CS-MS was fitting to Higuchi´s equation in PBS pH from 5.8 to 7.4. The plasma concentration versus time curve was coincident with one compartment model and the pharmacokinetics parameters were calculated by 3P97 program. The relative bioavailability of DS-CS-MS is 140.0% comparing to diclofenac sodium, together with SF/CS-MS, was a potential novel sustained-release carrier material with low toxicity due to its novel performance.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
The silk fibroin-chitosan loaded diclofenac sodium microspheres (DS-SF/CS-MS) were prepared with an emulsion crosslinking technique. The loading drug content and encapsulated efficiency of the obtained microspheres were (9.88±0.49)% and (50.35±0.92)%, respectively, with the average diameter was about (26.54±1.39)μm. The release profile of DS-SF/CS-MS was fitting to Higuchi´s equation in PBS pH from 5.8 to 7.4. The plasma concentration versus time curve was coincident with one compartment model and the pharmacokinetics parameters were calculated by 3P97 program. The relative bioavailability of DS-CS-MS is 140.0% comparing to diclofenac sodium, together with SF/CS-MS, was a potential novel sustained-release carrier material with low toxicity due to its novel performance.
Keywords
biomedical materials; drug delivery systems; materials preparation; molecular biophysics; polymer blends; proteins; 3P97 program; Higuchi equation; bioavailability; diclofenac sodium microspheres; drug content; emulsion crosslinking technique; encapsulated efficiency; microsphere sustained release; one compartment model; pH 5.8 to 7.4; pharmaceutical characteristics; pharmacokinetic parameters; pharmacokinetic profiles; plasma concentration-time curve; silk fibroin-chitosan; sustained release carrier material; Blood; Coatings; Drugs; Encapsulation; Loading; Materials; Scanning electron microscopy;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5780318
Filename
5780318
Link To Document