DocumentCode
3324649
Title
Notice of Retraction
Clinical Significance of VEGF,EGFR and BRCA-1 Expression in Non-Small Cell Lung Cancer
Author
Wang Linhui ; Li Yu
Author_Institution
Dept. of Pathology, Chongqing Med. Univ., Chongqing, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
4
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
To investigate the expressions of VEGF, EGFR and BRCA-1 proteins and their correlation in non-small-cell lung cancer (NSCLC), and to explore their clinical significance. Immunohistochemical staining with SP method was conducted to determine the expressions of VEGF, EGFR and BRCA-1 in 44 cases of NSCLC. The positive rate of VEGF, EGFR and BRCA-1 was 47.73% (21/44), 79.55% (35/44) and 50% (22/44) respectively. The expressions of VEGF and EGFR were not associated with gender, age, histopathological grading, lymphatic metastasis or smoking status (P>;0.05). But they were associated with clinical stage (P<;0.05). The expression of BRCA-1 was not associated with the clinical features above. The expression of BRCA-1 was positively correlated with the expression of VEGF in NSCLC (r=0.501, P=0.001). There was no significant correlation between VEGF and EGFR, EGFR and BRCA-1(P=0.344; P=0.147). VEGF, EGFR and BRCA-1 have important effects on the pathogenesis and development of NSCLC. Detection of the expressions of VEGF, EGFR and BRCA-1 may be of value in further understanding the biological behavior and predicting the prognosis of NSCLC.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
To investigate the expressions of VEGF, EGFR and BRCA-1 proteins and their correlation in non-small-cell lung cancer (NSCLC), and to explore their clinical significance. Immunohistochemical staining with SP method was conducted to determine the expressions of VEGF, EGFR and BRCA-1 in 44 cases of NSCLC. The positive rate of VEGF, EGFR and BRCA-1 was 47.73% (21/44), 79.55% (35/44) and 50% (22/44) respectively. The expressions of VEGF and EGFR were not associated with gender, age, histopathological grading, lymphatic metastasis or smoking status (P>;0.05). But they were associated with clinical stage (P<;0.05). The expression of BRCA-1 was not associated with the clinical features above. The expression of BRCA-1 was positively correlated with the expression of VEGF in NSCLC (r=0.501, P=0.001). There was no significant correlation between VEGF and EGFR, EGFR and BRCA-1(P=0.344; P=0.147). VEGF, EGFR and BRCA-1 have important effects on the pathogenesis and development of NSCLC. Detection of the expressions of VEGF, EGFR and BRCA-1 may be of value in further understanding the biological behavior and predicting the prognosis of NSCLC.
Keywords
cancer; cellular biophysics; lung; molecular biophysics; proteins; BRCA-1 protein expression; EGFR protein expression; NSCLC prognosis prediction; VEGF protein expression; biological behavior; immunohistochemical staining; nonsmall cell lung cancer; Breast cancer; Correlation; Lungs; Medical treatment; Metastasis; Tumors;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5780415
Filename
5780415
Link To Document