Notice of RetractionThe Effects of Ethanol Extracts from Forsythia Suspensa against Antibiotic-Resistant Streptococcus suis Isolates In Vivo and In Vitro

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

Forsythia suspensa extracts, isolated from the air-dried fruit of Forsythia suspensa, is a common traditional Chinese medicine recorded in Chinese Pharmacopeia. To evaluate the in vitro antibacterial activity of Forsythia suspensa extract, the minimum inhibitory concentration (MIC) was determined using a microtitre assay. For in vivo investigation, 50 Kunming mice were used, groups 1 to 4 (10 per group) were inoculated intraperitoneally with 1 ml of S. suis (LD₅₀ CFU/ml) and treated orally 3 times per day for 7 days with: group 1,group 2, group 3 and group 4. Another group (group 5) of 10 mice were control group. Serial dilutions of the lung homogenates were counted after an 18 hour incubation at 37°C.Ethanol extracts of Forsythia suspensa showed significant bacteriostatic activity against all tested strains of S. suis with MICs all greater than 1.562 mg/ml, especially the amoxicillin-resistant strains. When tested in vivo, a 1:4 mixture of amoxicillin and Forsythia suspense extract had the greatest protective effect on mice against S. suis, followed by Forsythia suspensa extract alone.