Title :
Notice of Retraction
The Screening of Anti-Hepatoma Components from Total Aqueous Extracts of Artemisia argyi
Author :
Yu Xin ; Yin Meizhen ; Wang Jinghui ; Cao Feng ; Xiao Anju ; Lu Zheng ; Yu Geshu
Author_Institution :
Sch. of Med., Huangshi Inst. of Technol., Huangshi, China
Abstract :
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Objective: Screening the components with anti hepatoma activity from aqueous extract of Artemisia argyi. Method: Aqueous extracts with or without polysaccharide and polysaccharide extract were prepared from Artemisia argyi. The anti-hepatoma activity of them at different concentrations was evaluated in vitro with an inverted microscope for observing live cells and with MTT test. Results: After 24h~48h treatment of HepG2 cells, the aqueous extracts with/without polysaccharide led to the morphological change of the cell, the significant decrease of OD values, compared with control group (P<;0.01), and ultimately the death of the cell. Polysaccharide extract at the concentrations of 17.5 mg(Artemisia argyi)/mL and 35 mg(Artemisia argyi)/mL lead to no morphological change, while the slight decrease of OD values, compared with control group (P>;0.05), and at the concentrations of 70 mg(Artemisia argyi)/mL lead to cell contractility, and decrease of OD values, compared with control group (P<;0.05). Cone I us ion : The aqueous extracts with/without polysaccharide could lead to the shrinkage of hepatocellular carcinoma cell, block cell proliferation and induce cell death. The polysaccharide extract had weaker anti-hepatoma activity and could inhibit cell proliferation. Screening the components or leading compounds with anti-cancer activity from the aqueous extract without polysaccharide of Artemisia argyi is under the way.
Keywords :
biochemistry; botany; cellular biophysics; Artemisia Argyi; MTT test; antihepatoma components screening; cell contractility; cell death; cell proliferation; hepatocellular carcinoma cell shrinkage; inverted microscope; polysaccharide extract; time 24 h to 48 h; total aqueous extracts; Drugs; Ethanol; Humans; Microscopy; Morphology; Optical filters;
Conference_Titel :
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location :
Wuhan
Print_ISBN :
978-1-4244-5088-6
DOI :
10.1109/icbbe.2011.5780434