DocumentCode
3325013
Title
Notice of Retraction
Immunomodulation and Antitumor Activities of Dicrateria sp. Polysaccharide
Author
Wang Ling ; Sun Liqin ; Zhou Yan ; Su Hang ; Wang Changhai
Author_Institution
Ocean Sch., Yantai Univ., Yantai, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
4
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
The polysaccharides (DPAs) isolated from Dicrateria sp. were separated and purified The antitumor and immunomodulatory activities of polysaccharides were evaluated by the S180-tumor-bearing mouse model in vivo and peritoneal macrophage and spleen lymphocyte activation in vitro. The results showed that different doses of DAPs significantly inhibited the growth of implanted S180 tumor and stimulated the proliferation of mouse spleen lymphocytes. The tumor inhibition index at high was 51.35%. The different molecular weight polysaccharides (DAP-1 and DAP-2) all showed obviously immunostimulatory effect. The specific manifestation showed that the polysaccharides promoted the NO release in mouse peritoneal macrophages, increased neutral red uptake in mouse peritoneal macrophages, and stimulated the proliferation of spleen lymphocyte by peritoneal macrophages.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
The polysaccharides (DPAs) isolated from Dicrateria sp. were separated and purified The antitumor and immunomodulatory activities of polysaccharides were evaluated by the S180-tumor-bearing mouse model in vivo and peritoneal macrophage and spleen lymphocyte activation in vitro. The results showed that different doses of DAPs significantly inhibited the growth of implanted S180 tumor and stimulated the proliferation of mouse spleen lymphocytes. The tumor inhibition index at high was 51.35%. The different molecular weight polysaccharides (DAP-1 and DAP-2) all showed obviously immunostimulatory effect. The specific manifestation showed that the polysaccharides promoted the NO release in mouse peritoneal macrophages, increased neutral red uptake in mouse peritoneal macrophages, and stimulated the proliferation of spleen lymphocyte by peritoneal macrophages.
Keywords
cellular biophysics; molecular weight; organic compounds; tumours; Dicrateria sp. polysaccharide; S180-tumor-bearing mouse model; antitumor activity; immunomodulation; molecular weight; peritoneal macrophage; spleen lymphocyte activation; tumor inhibition index; Algae; Drugs; Immune system; In vitro; Indexes; Mice; Tumors;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5780436
Filename
5780436
Link To Document