Title :
Notice of Retraction
Evaluation of Antidepressant Activity of GUAN-1001 in Various Experiment Antidepressant Models in Mice
Author :
Li-Ping Guan ; You-Le Qu
Author_Institution :
Food & Pharmacy Coll., Zhejiang Ocean Univ., Zhoushan, China
Abstract :
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
A new N-cinnamamide derivatives GUAN 1001 (N-(3-hydroxypropyl)cinnamamide) was tested the forced swimming test and the tail suspension test for antidepressant activity in mice. The forced swimming test(FST) and the tail suspension test(TST) showed that GUAN-1001 was found to be better active and reduced the duration of immobility time by 23.36 % and 18.97%, respectively, at a dose of 10 mg/kg compared with the control (p <; 0.01 and p <;0.05). And it was observed GUAN 1001 at dose of 10, 20 and 40 mg/kg significantly reduced the duration of immobility times in the FST in mice 30 min after treatment.
Keywords :
biochemistry; biomechanics; biomedical materials; drugs; neurophysiology; organic compounds; patient treatment; psychology; GUAN-1001; N-(3-hydroxypropyl)cinnamamide; antidepressant activity; antidepressant mice models; forced swimming test; tail suspension test; time 30 min; Antidepressants; Compounds; Laboratories; Mice; Suspensions;
Conference_Titel :
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location :
Wuhan
Print_ISBN :
978-1-4244-5088-6
DOI :
10.1109/icbbe.2011.5780441
