Title :
Sokoloff and Patlak methods for CMRGlu quantification with aortic image-derived input function: A feasibility study
Author :
Vanzi, Eleonora ; Berti, Valentina ; Freddi, Haria ; Polito, Cristina ; Comis, Giannetto ; Pupi, Alberto
Author_Institution :
Dept. of Clinical Pathophysiology, Univ. of Florence, Florence, Italy
Abstract :
Quantitative maps of CMRGlu (mumol/min/100g) from FDG-PET are useful in neurodegenerative disorders studies but require practical methods to be used in the clinical routine. We propose a method based on aortic image-derived input function (IF) and the quantification methods from Sokoloff and Patlak. Five patients were analyzed with the proposed method and numerical simulations were designed to test the bias that can affect CMRGlu estimates.
Keywords :
medical disorders; neurophysiology; numerical analysis; positron emission tomography; CMRG1u quantification; FDG-PET; Patlak methods; Sokoloff methods; aortic image-derived input function; neurodegenerative disorders; numerical simulation; quantification methods; Biomedical imaging; Numerical models;
Conference_Titel :
Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2011 IEEE
Conference_Location :
Valencia
Print_ISBN :
978-1-4673-0118-3
DOI :
10.1109/NSSMIC.2011.6152557
