Title :
Microfluidic chamber array for generating concentration gradients
Author :
Yamada, Masumi ; Seki, Minoru
Author_Institution :
Dept. of Chem. & Biotechnol., Univ. of Tokyo, Japan
Abstract :
A novel microfluidic chamber array system has been developed. This system consists of three-dimensional microchannel and microchamber network, in which nanoliter sized multiple droplets can be accurately metered and mixed simultaneously. Liquid operation was realized using pneumatic pressure due to the hydrophobic surface nature of PDMS microdevice. With this device, single injection of liquid is enough to prepare various sized aliquots, and by mixing two different kinds of liquids, concentration gradient can easily be generated. This system can further be applied to chemical or biochemical analysis, such as, high-throughput screening or blood analysis for point-of-care diagnosis.
Keywords :
biochemistry; chemical analysis; drops; microfluidics; PDMS microdevice; accurately metered; aliquots; biochemical analysis; blood analysis; chemical analysis; generating concentration gradients; high-throughput screening; hydrophobic surface nature; liquid operation; microfluidic chamber array; mixed; nanoliter sized multiple droplets; pneumatic pressure; point-of-care diagnosis; Biochemical analysis; Chemicals; Chemistry; Fabrication; Liquids; Microchannel; Microfluidics; Surface treatment; Valves; Vents;
Conference_Titel :
Micro Electro Mechanical Systems, 2003. MEMS-03 Kyoto. IEEE The Sixteenth Annual International Conference on
Print_ISBN :
0-7803-7744-3
DOI :
10.1109/MEMSYS.2003.1189757
