Simulation and experiment on biological tissue for near infra-red (NIR) photon migration in a multi-layered model

Author

Haishu, Ding ; Chan, Su ; Fang, Lin ; Feng, Wang ; Jinpin, Ying

Author_Institution

Dept. of Electr. Eng., Tsinghua Univ., Beijing, China

Volume

2

fYear

1998

fDate

29 Oct-1 Nov 1998

Firstpage

932

Abstract

To study the phenomenon of infrared photon migration in a multi-layered tissue is very useful in biomedical applications such as noninvasive optical monitoring of physiological parameters and the optimal dosimetry of photodynamic therapy. Multi-layered models for the research of NIR light propagation in biological tissue are established using Monte-Carlo simulation. Photon tracking and parameter correcting methods across the boundary of tissue layers with mismatched optical properties are provided. Experimental results on animal tissue are presented, and a close relationship has been found between the actual measurement and the simulation

Keywords

Monte Carlo methods; bio-optics; biological tissues; light propagation; photodynamic therapy; physiological models; Monte-Carlo simulation; animal tissue; biological tissue experiment; biological tissue simulation; mismatched optical properties; multilayered model; near infra-red photon migration; noninvasive optical monitoring; optimal dosimetry; parameter correcting methods; photon tracking; physiological parameters; tissue layer boundaries; Animals; Biological system modeling; Biological tissues; Biomedical monitoring; Biomedical optical imaging; Condition monitoring; Dosimetry; Infrared surveillance; Medical treatment; Optical propagation;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE

Conference_Location

Hong Kong

ISSN

1094-687X

Print_ISBN

0-7803-5164-9

Type

conf

DOI

10.1109/IEMBS.1998.745596

Filename

745596