Hemodynamic assessment by evaluation of intramyocardial electrograms

The influence of hemodynamic variation on intramyocardial electrograms was investigated by combining clinical intramyocardial electrogram recordings with computerized modeling of the heart. Paced intramyocardial electrograms were recorded in heart transplant patients using telemetric pacemakers. Different hemodynamic filling states of the heart have been achieved by variation of the pacing rate. The results of the regression analysis between the pacing rate and parameters of the depolarization phase were used to set the parameters of the computer model that allows to simulate the origination of the ventricular evoked response and to consider influences of geometric variation. The experimental and theoretical results show a distinct and comparable impact of the hemodynamic state of the heart on the depolarization phase of paced intramyocardial electrograms