Mining the Bioinformation of Differentially Expressed Genes in Rats Treated by Diesel Exhaust Inhalation Based on the Bioinformatics Methods

Author

Bi, De ; Xiao, Huajun ; Zhou, Cuihong ; Zhou, Jun

Author_Institution

Dept. of Man-Machine-Environ. Syst. Eng., Beihang Univ. (BUAA), Beijing, China

fYear

2011

fDate

10-12 May 2011

Firstpage

1

Lastpage

4

Abstract

Objective: To analyze the differentially expressed genes expressed genes in rats that inhaled diesel exhaust (DE) for getting better understanding of the molecular characteristics caused by particle in the public environment. Methods: Got the microarray hybridization data from the Gene Expression Omnibus (GEO) database. Identified the differentially expressed genes expressed genes in DE rats and the patterns of their regulation using public bioinformatics software and database, which involved BRB-Arraytools, PANTHER and DAVID, KEGG. Results and Conclusion: These data mining findings between air and DE rats by bioinformatics methods could provide better understanding of the molecular activity change caused by DE.

Keywords

bioinformatics; data mining; genetics; BRB-Arraytools; DAVID; KEGG; PANTHER; bioinformatics methods; bioinformation mining; diesel exhaust inhalation; differentially expressed genes; gene expression omnibus database; microarray hybridization data; molecular characteristics; public bioinformatics software; Bioinformatics; Data mining; Gene expression; Immune system; Proteins; Rats;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on

Conference_Location

Wuhan

ISSN

2151-7614

Print_ISBN

978-1-4244-5088-6

Type

conf

DOI

10.1109/icbbe.2011.5781236

Filename

5781236