DocumentCode
3343308
Title
Notice of Retraction
Direct Chiral Resolution and Determination of Enantiomeric Ratio of Lambda-Cyhalothrin in Rabbits by High-Performance Liquid Chromatography
Author
Yiping Liu ; Xiaogang Li ; Changdi Hu ; Lianyang Bai
Author_Institution
Colleage of Bio-safety Sci. & Technol., Hunan Agric. Univ., Changsha, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
5
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
ChirsA pesticides currently constitute about 50% of all pesticides dosage used in China, and this ratio is increasing as more complex structres compouds are introduced into use. Lambda-cyhalothrin (LCT) is a chiral insecticide consisting of a pair of enantiomers. The enantioselectivity separation of lambda-cyhalothrin was studied on cellulose tris-(3, 5-dimethylphenylcarbamate)-coated chiral stationary phase (CDMPC-CSP) using normal phase high-performance liquid chromatography (NP-HPLC). The effects of the mobile phase composition, flow rate and column temperature on enantiomers separation were determined. A chiral high-performance liquid chromatography method was developed and validated for stereoselective determination of lambda-cyhalothrin in rabbits. The results showed that good separation was achieved at 25°C using cellulose tris-(3, 5-dimethylphenylcarbamate) as chiral stationary phase, a mixture of n-hexane and iso-propanol (92:8) as mobile phase at a flow rate of 1.0 ml/min. The assay method was linear over a range of concentrations (0.1-50 μg/ml) in plasma and the mean recovery was greater than 80% for both enantiomers. The limits of detection for both enantiomers in plasma were 0.1 μg/ml. Intraand interday coefficient of variation (CVs) did not exceed 15% for three-tested concentrations. The method was successfully applied to determination enantiomer ratio (ER) of LCT in rabbits. The result suggested that the degradation of LCT enantiomers was stereoselective in rabbits.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
ChirsA pesticides currently constitute about 50% of all pesticides dosage used in China, and this ratio is increasing as more complex structres compouds are introduced into use. Lambda-cyhalothrin (LCT) is a chiral insecticide consisting of a pair of enantiomers. The enantioselectivity separation of lambda-cyhalothrin was studied on cellulose tris-(3, 5-dimethylphenylcarbamate)-coated chiral stationary phase (CDMPC-CSP) using normal phase high-performance liquid chromatography (NP-HPLC). The effects of the mobile phase composition, flow rate and column temperature on enantiomers separation were determined. A chiral high-performance liquid chromatography method was developed and validated for stereoselective determination of lambda-cyhalothrin in rabbits. The results showed that good separation was achieved at 25°C using cellulose tris-(3, 5-dimethylphenylcarbamate) as chiral stationary phase, a mixture of n-hexane and iso-propanol (92:8) as mobile phase at a flow rate of 1.0 ml/min. The assay method was linear over a range of concentrations (0.1-50 μg/ml) in plasma and the mean recovery was greater than 80% for both enantiomers. The limits of detection for both enantiomers in plasma were 0.1 μg/ml. Intraand interday coefficient of variation (CVs) did not exceed 15% for three-tested concentrations. The method was successfully applied to determination enantiomer ratio (ER) of LCT in rabbits. The result suggested that the degradation of LCT enantiomers was stereoselective in rabbits.
Keywords
agrochemicals; chemical products; chromatography; health hazards; isomerism; toxicology; China; cellulose tris-(3, 5-dimethylphenylcarbamate); coatings; coefficient of variation; column temperature; complex structres compouds; direct chiral resolution; enantiomeric ratio; enantiomers; enantioselectivity separation; high-performance liquid chromatography; insecticide; lambda-cyhalothrin; mean recovery; mobile phase composition; pesticides; rabbits; stereoselective determination; temperature 25 degC; Degradation; Heart; Liver; Mobile communication; Plasma temperature; Rabbits;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5781398
Filename
5781398
Link To Document