Notice of RetractionEffect of Formaldehyde Exposure on CYP450 of Liver Cells of Mice

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

In order to explore the influence of CYP450 in the liver of mice after inhalation of formaldehyde, using SPF level purely Kunming male mice for the study, set 4 concentrations of gaseous formaldehyde dynamics: 0, 0.5, 1.0 and 3.0 mg/m³ in mice exposed to continuous 72 hours, then measured changes of total contents of CYP450 in the liver microsomes, and detected the varieties of CYP1B1 by RT-PCR technology, which plays an important part in activating carcinogens. The results showed: At the concentration range of formaldehyde set in this study, there is a visible difference in the contents of total CYP450 and CYP1B1 between exposure group and control group. This study suggests that FA can make change of CYP450 in the liver of mice, whose gene polymorphism are related to cancer.