Notice of RetractionThe Effects of Trichlorfon on Estrous Cycle and Developmental Outcomes in Female Mice

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

Trichlorfon (TCF) is a widely used broad-spectrum agricultural organophosphorus (OP) pesticide. Few studies have evaluated the effects of TCF on reproductive toxicity after low level exposure, especially long-term exposure. In this study we assessed the direct effects of TCF on estrous cycle in female mice and developmental outcomes in near-term fetuses after consecutive 30 days of maternal exposure to 2, 10 and 50 mg/kg body weight/day TCF via drinking water. Both male and female fetuses in the 50 mg/kg/day TCF treated group had significantly reduced body weight but not in 2 mg/kg/day and 10 mg/kg/day. There was no difference in estrous cycle between the control and TCF-treated groups. No increased incidence of fetal external malformations was observed in the TCF-treated groups. The lack of effects of TCF of 2 mg/kg/day and 10 mg/kg/day on any in vivo reproductive and developmental endpoints above suggested that for TCF, a hazard of reproductive toxicity below 10 mg/kg/d may not be expected. However, a significant decrease in fetal body weight was observed in the 50 mg/kg/day TCF treated group, suggesting that potential adverse health effects of OP pesticides exposure should continue to be carefully studied in the future.