Instrumentation setup for simultaneous measurement of optical and positron labeled probes in mice

Author

Peter, Jörg ; Schmitz, Jenifer ; Christ, Usrula ; Haberkorn, Uwe

Author_Institution

German Cancer Res. Center (DKFZ), Heidelberg, Germany

fYear

2011

fDate

23-29 Oct. 2011

Firstpage

2306

Lastpage

2308

Abstract

A unique optical imaging instrument for fully 360 degree bioluminescence imaging (BLI) and multispectral fluorescence imaging and tomography (FMI/FMT) has been designed and constructed that can be incorporated into any dedicated unmodified small animal PET system with a minimum bore opening diameter of 125 mm. By way of example, an integrated setup for bimodal imaging will be described which has been tailored to the Siemens Inveon PET. The optical imager consists of a cylindrical (hexagonal) rotatable assembly of six microlens-based 25mm×100mm flat panel photon sensors and a variety of light sources for fluorochrome excitation. We present results in the form of simultaneously acquired phantom data as well as of two mouse imaging studies (BLI-PET, FMI-PET) that illustrate the capabilities of this novel approach. Further technical improvements are also presented and discussed such as a novel approach for calculating three-dimensional optical surface images from segmented emission PET data when a strong background signal is present (F18-FDG).

Keywords

bioluminescence; biomedical optical imaging; fluorescence; image segmentation; light sources; medical image processing; phantoms; positron emission tomography; bioluminescence imaging; flat panel photon sensors; fluorochrome excitation; light sources; multispectral fluorescence imaging; multispectral fluorescence tomography; optical imaging instrument; optical labeled probes; positron labeled probes; segmented emission PET data; siemens inveon PET; simultaneous measurement; simultaneously acquired phantom data; small animal PET system; three-dimensional optical surface imaging; two mouse imaging; wavelength 125 mm; CMOS integrated circuits; Instruments; dual-modality imaging; optical imaging; positron emission tomography; small animal imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2011 IEEE

Conference_Location

Valencia

ISSN

1082-3654

Print_ISBN

978-1-4673-0118-3

Type

conf

DOI

10.1109/NSSMIC.2011.6153868

Filename

6153868