Notice of RetractionAlternol Inhibits Proliferation and Induces Apoptosis in Human Leukemia HL-60 Cells

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

Alternol is purified from fermentation production of microorganisms named as Alternaria alternata var. monosporus. This research is to investigate the apoptosis-inducing by alternol in human pro myelocytic leukemia HL-60 cells. SRB method was used to evaluate the viability of HL-60 cells. Flow cytometry assay was used to examine the apoptosis rate of HL-60 cells and AO/EB staining was used to observe cell morphology. JC-1 staining was used to detect the change of mitochondria membrane potential in HL-60 cells. The proliferation of HL-60 cells was inhibited remarkably in a time-dependent and dose-dependent manner by alternol; the mitochondria membrane potential of HL-60 cells decreased. The results indicate that alternol is a potential agent for leukemia chemo-therapy.