DocumentCode
3347684
Title
Notice of Retraction
Construction of Recombinant Rabbit Hemorrhagic Disease Virus (RHDV) Vaccine Using Myxoma Virus (MV) as a Vector
Author
Zhen Guo ; Yuan Wang ; Qian Yu ; Jie Xiao ; Kaiyu Liu ; Ying Wang ; Commeyras, A. ; Yi Li
Author_Institution
Coll. of Life Sci., Huazhong Normal Univ., Wuhan, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
4
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Rabbit hemorrhagic disease virus (RHDV) and myxoma virus (MV) are the two main viruses that cause serious virus diseases in rabbit population. MV, a pox virus, has been proved to be a good recombinant vaccine vector. In this study we have developed a recombinant virus using MV as a vector against both the myxomatosis and rabbit hemorrhagic disease (RHD). We used the nonessential gene MST3N of MV as the insertion site. The recombinant viruses expressed the RHDV major capsid protein (VP60) and the selectable marker GFP. The pure recombinant viruses were achieved after several rounds of plaque screening. Replication of MST3N-knockout recombinant virus MV-VP60 in Rabbit kidney cell (RK13) was unimpaired, compared with wild type virus MV.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Rabbit hemorrhagic disease virus (RHDV) and myxoma virus (MV) are the two main viruses that cause serious virus diseases in rabbit population. MV, a pox virus, has been proved to be a good recombinant vaccine vector. In this study we have developed a recombinant virus using MV as a vector against both the myxomatosis and rabbit hemorrhagic disease (RHD). We used the nonessential gene MST3N of MV as the insertion site. The recombinant viruses expressed the RHDV major capsid protein (VP60) and the selectable marker GFP. The pure recombinant viruses were achieved after several rounds of plaque screening. Replication of MST3N-knockout recombinant virus MV-VP60 in Rabbit kidney cell (RK13) was unimpaired, compared with wild type virus MV.
Keywords
cellular biophysics; diseases; kidney; microorganisms; proteins; zoology; GFP marker; MST3N gene; RHDV vaccine; RK13 cell; Rabbit kidney cell; VP60 protein; myxoma virus; plaque screening; rabbit population; recombinant rabbit hemorrhagic disease virus; Diseases; Hemorrhaging; Immune system; Proteins; Rabbits; Vaccines; Viruses (medical);
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5781650
Filename
5781650
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