Notice of RetractionPreparation and Characterization of Mn0.5Zn0.5Fe2O4 @Au Composite Nanoparticles and Its Anti-Tumor Effect on Hepatocellular Carcinoma Cells

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To explore the preparation method and characters of a new gold nanoshells on maganese-zinc ferrite(Mn_0.5Zn_0.5Fe₂O₄@Au) composite nanoparticles. Mn_0.5Zn_0.5Fe₂O₄@Au nanoparticles with core/shell structure were synthesized by reduction of Au with trisodium citrate in the presence of Mn_0.5Zn_0.5Fe₂O₄ magnetic nanoparticles(MZF NPs) prepared by improved co-preciption with the character of superparamagnetism and detected by transmission electron microscopy(TEM), scanning electron microscopy(SEM), x-ray diffraction(XRD), energy dispersive spectrometry(EDS) and Marven laser particle size analyzer.Thermodynamic test was used to observe temperature change of various doses of Mn_0.5Zn_0.5Fe₂O₄@Au nanoparticles. The cytotoxicity of the Mn_0.5Zn_0.5Fe₂O₄@Au composite nanoparticles in vitro was tested by the MTT assay. The therapeutic effect of Mn_0.5Zn_0.5Fe₂O₄@Au composite nanoparticles combined with magnetic fluid hyperthermia (MFH) on hepatocellular carcinoma cells were evaluated in vitro by an MTT assay.The results indicated that the Mn_0.5Zn_0.5Fe₂O₄@Au composite nanoparticles were prepared successfully. The core/shell particles with superparemagnetic properties due to their Fe oxide cores were spherical and exact average diame- er of them was 66.9nm.EDS showed each Mn_0.5Zn_0.5Fe₂O₄@Au nanoparticle contained Mn, Zn, Fe, O and Au elements, and this proved Au had successfully attached to Mn_0.5Zn_0.5Fe₂O₄. The result of thermodynamic test showed that Mn_0.5Zn_0.5Fe₂O₄@Au composite nanoparticles could serve as a heating source under alternating magnetic field- AMF) exposure leading to reach their steady temperature(40-45°C). Moreover, Mn_0.5Zn_0.5Fe₂O₄@Au composite nanoparticles didn´t show cytotoxicity in vitro. The therapeutic result reveals that Mn_0.5Zn_0.5Fe₂O₄@Au composite nanoparticles can significantly inhibit the growth of hepatocellular carcinoma cells.The conclusion was that the self-prepared Mn_0.5Zn_0.5Fe₂O₄@Au composite nanoparticles had strong magnetic responsiveness and good power absorption capabilities in the high frequency AMF,then they could suggested to be useful for hepatocellular carcinoma hyperthemia. Mn_0.5Zn_0.5Fe₂O₄@Au composite nanoparticles can not only be directed to tumor region in a given magnetic field more exactly but also produce marked thermotherapy.