An improved biophysical model of electroporation of cell membrane

In this paper, the author has improved a model of electroporation of cell membrane in a biological system. The improved model elucidates that: the critical potential difference Δψ₀ of electroporation is proportional to _gτ0/2^mL2 and exp(_RT/^ΔEd), where m, L and q are respectively mass, thickness and net charge of a membrane patch; τ ₀ is the critical time width of the externally imposed electric pulse; R is the gas constant; T is the absolute temperature of an electroporation system and ΔE_d (>0) is a thermodynamic energy of molecules in the cell membrane. ΔE_d is equal to an absolute value of a dragging energy bond of molecules in the interface between a patch and a cell. ΔE_d has been obtained and it is at a level of an absolute value of a hydrogen bond energy (5.44 kcal/mole) by fitting a set of experimental data