Title :
Demonstration of molecular upconvertors
Author :
Faris, G.W. ; Dyer, M.J.
Author_Institution :
Molecular Phys. Lab., SRI Int., Menlo Park, CA, USA
Abstract :
Summary form only given. We report on a new type of optical reporter suitable for in vivo and in vitro diagnostics: molecular upconvertors. These reporters consist of single lanthanide ions held by a chelating ligand. These reporters have properties that are advantageous for use in biomedical diagnostics. These reporters have many of the properties of upconverting phosphor reporters-no autofluorescence, multiplexing capabilities, no photobleaching, and excitation with compact and low power diode lasers-but in a molecular scale reporter.
Keywords :
fluorescence spectroscopy; laser applications in medicine; patient diagnosis; phosphors; biomedical diagnostics; chelating ligand; in vitro diagnostics; in vivo diagnostics; low power diode lasers; molecular scale reporter; molecular upconvertors; multiplexing capabilities; optical reporter; single lanthanide ions; upconverting phosphors; Biomedical imaging; Biomedical optical imaging; Coherence; High speed optical techniques; Humans; In vivo; Medical diagnostic imaging; Neoplasms; Optical distortion; Optical imaging;
Conference_Titel :
Quantum Electronics and Laser Science Conference, 1999. QELS '99. Technical Digest. Summaries of Papers Presented at the
Conference_Location :
Baltimore, MD, USA
Print_ISBN :
1-55752-576-X
DOI :
10.1109/QELS.1999.807647
