Title :
Validation of a Na+-Ca++ regulation model for high variations of the inner cell conditions
Author :
González-Vélez, V. ; Godínez-Fernández, J.R. ; Aguilar-Pliego, J. ; Morales-Guzmán, J.D.
Author_Institution :
Dept. of Basic. Sci., UAM, Azcapotzalco, Mexico
Abstract :
The Na+-Ca++ exchanger is a reversible regulation mechanism which can work to deplete or augment the internal Ca++ concentration, as long as there is enough free Na+ . A Ca++ regulation simulator has been demonstrated to be reliable for simulating the cell response to ionic and electrical stimuli, providing the internal Ca++ concentration is in the physiological range at the beginning of the simulation. In this paper, we pose several corrections to the original model and we also discuss the inclusion of additional kinetic and sensitivity parameters of the mechanisms in order to follow the biological role of the exchanging current
Keywords :
biocontrol; bioelectric phenomena; biomembrane transport; calcium; ion exchange; simulation; sodium; Na+-Ca2+ regulation model validation; biological role; cell membranes; cell response; electrical stimuli; electrogenic regulation mechanism; exchanging current; internal Ca2+ concentration; ion exchanger; ionic stimuli; kinetic parameters; physiological range; reversible regulation mechanism; sensitivity parameters; simulation; variable inner cell conditions; Biological system modeling; Biomembranes; Biophysics; Cells (biology); Equations; Kinetic theory; Magnetic resonance; Plasmas; Protocols; Voltage;
Conference_Titel :
Computer-Based Medical Systems, 2001. CBMS 2001. Proceedings. 14th IEEE Symposium on
Conference_Location :
Bethesda, MD
Print_ISBN :
0-7695-1004-3
DOI :
10.1109/CBMS.2001.941755
