DocumentCode :
336303
Title :
Early detection of bronchiolitis obliterans syndrome in lung transplant recipients with chronic rejection using home spirometry
Author :
Finkelstein, SM ; Hertz, MI ; Snyder, M ; Stibbe, C. Edin ; Sabati, N. ; Lindgren, B. ; Dutta, P. ; Killoren, T. ; Slagle, J.
Author_Institution :
Minnesota Univ., Minneapolis, MN, USA
Volume :
3
fYear :
1997
fDate :
30 Oct-2 Nov 1997
Firstpage :
1070
Abstract :
Declining pulmonary function, as measured by staging for bronchiolitis obliterans syndrome, is considered primary indication of future chronic rejection in transplanted lungs. Staging has been evaluated in a group of transplant recipients using a paperless, electronic spirometer/diary instrument for home monitoring. Eleven of 104 lung recipients were diagnosed with chronic rejection. Seven of these subjects had performed home monitoring for a minimum of 8 months at the time of this study. Clinic and home spirometry variables were used in the staging algorithm to determine the onset and rate of clinical decline related to the rejection. Using home spirometry, the onset of decline began an average of 284 days before diagnosis of chronic rejection, which was significantly earlier (p<0.05) than the decline observed with clinic pulmonary function testing. Staging changes based on home spirometry preceded diagnosis of chronic rejection in all subjects, but only occurred in 4 of 7 subjects using clinic testing. Home spirometry can provide early and consistent indication of pulmonary decline prior to chronic rejection, and should be considered as a future component of post-transplant follow-up care
Keywords :
lung; medical signal detection; patient monitoring; pneumodynamics; surgery; 284 d; 8 month; bronchiolitis obliterans syndrome early detection; clinical decline rate; future chronic rejection; home monitoring; home spirometry; lung transplant recipients; paperless electronic spirometer/diary instrument; post-transplant follow-up care; staging algorithm; Cardiac disease; Cardiovascular diseases; Instruments; Lungs; Monitoring; Protocols; Pulse measurements; Samarium; Testing; USA Councils;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
ISSN :
1094-687X
Print_ISBN :
0-7803-4262-3
Type :
conf
DOI :
10.1109/IEMBS.1997.756533
Filename :
756533
Link To Document :
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