DocumentCode :
3366011
Title :
A system for detecting chemically-induced changes in cerebral blood flow using transcranial Doppler sonography in a dog model
Author :
Drues, Michael E. ; Hopper, David L. ; Lange, Douglas N.
Author_Institution :
Iowa State Univ., Ames, IA, USA
fYear :
1992
fDate :
14-17 Jun 1992
Firstpage :
477
Lastpage :
485
Abstract :
An experiment designed to develop a computer-based system capable of detecting chemically induced changes in cerebral blood flow (CBF) in a dog before the onset of overt clinical or behavioral symptoms is discussed. The system uses transcranial Doppler sonography (TCD) to noninvasively measure changes in CBF after low-level exposure to deltamethrin. Since changes in CBF often occur before other clinical signs, a method of detecting these changes could be used to detect exposures to potentially hazardous chemicals. Initial results indicate that TCD does seem to be sensitive enough to detect changes in blood flow velocity caused by deltamethrin, but improvements in the methodology need to be made and more data need to be collected to try to obtain more consistent results
Keywords :
Doppler effect; biomedical ultrasonics; brain; flow measurement; haemodynamics; patient diagnosis; behavioral symptoms; cerebral blood flow; chemically induced changes; computer-based system; deltamethrin; dog model; transcranial Doppler sonography; Animals; Arteries; Biomedical measurements; Blood flow; Chemical hazards; Fluid flow measurement; Humans; Ultrasonic imaging; Ultrasonic variables measurement; Ultrasonography;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Computer-Based Medical Systems, 1992. Proceedings., Fifth Annual IEEE Symposium on
Conference_Location :
Durham, NC
Print_ISBN :
0-8186-2742-5
Type :
conf
DOI :
10.1109/CBMS.1992.245004
Filename :
245004
Link To Document :
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