A cultured neuron probe

Author

Pine, Jerome ; Maher, Michael ; Potter, Steven ; Tai, Yu-Chong ; Tatic-Lucic, Svetlana ; Wright, John ; Buzsaki, Gyorgy ; Bragin, Anatol

Author_Institution

California Inst. of Technol., Pasadena, CA, USA

Volume

5

fYear

1996

fDate

31 Oct-3 Nov 1996

Firstpage

2133

Abstract

Work in progress toward the creation of a “cultured neuron probe” is described. This is a silicon structure similar to that for a multielectrode probe, but with embedded neurons which are intended to grow out and integrate with the neurons of a host nervous system into which the probe has been inserted. Each probe neuron is in close proximity to an electrode which is designed for extracellular estimation and recording from the probe neuron. In this way the probe neurons may provide a highly specific long-term communication link between external electronics and the host. Initial experiments to establish the feasibility of the concept will be done in rat hippocampus

Keywords

bioelectric phenomena; biological techniques; cellular biophysics; electrodes; neurophysiology; probes; Si; cultured neuron probe; embedded neurons; external electronics; extracellular estimation; extracellular recording; highly specific long-term communication link; host nervous system; multielectrode probe; rat hippocampus; silicon structure; Central nervous system; Electrodes; Embryo; Extracellular; Hippocampus; Independent component analysis; Nervous system; Neurons; Probes; Silicon;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE

Conference_Location

Amsterdam

Print_ISBN

0-7803-3811-1

Type

conf

DOI

10.1109/IEMBS.1996.646466

Filename

646466