Contraction Measurements of Cardiomyocytes Grown on Silicon Cantilevers

Author

Todorova, M. ; Stücklin, Ph ; Bertsch, A. ; Rohr, S. ; Renaud, Ph

Author_Institution

Microsystems Lab., Lausanne

fYear

2007

fDate

10-14 June 2007

Firstpage

17

Lastpage

19

Abstract

Microcantilevers on polysilicon were manufactured and living cardiomyocytes cells from neonatal rat hearts were cultured on top of them. The cells self-organize and start to contract after three days incubation. Moving the beams on which they are attached allows the measurement of the contractile force exerted by the cardiomyocytes. With this simple setup, the evaluation of the mechanical response of the cells due to changes in medium composition or temperature can be performed.

Keywords

biomechanics; biomedical measurement; cantilevers; cardiology; cellular biophysics; force measurement; micromechanical devices; silicon; cardiomyocytes contraction; contractile force measurement; contraction measurements; living cardiomyocytes cells; mechanical response; microcantilevers; neonatal rat hearts; polysilicon; silicon cantilevers; three-day incubation; Cardiology; Cells (biology); Contracts; Force measurement; Heart; Manufacturing; Pediatrics; Performance evaluation; Silicon; Temperature; cardiomyocyte contraction; mechanical response; silicon cantilevers;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International

Conference_Location

Lyon

Print_ISBN

1-4244-0842-3

Electronic_ISBN

1-4244-0842-3

Type

conf

DOI

10.1109/SENSOR.2007.4300061

Filename

4300061