Title :
Contraction Measurements of Cardiomyocytes Grown on Silicon Cantilevers
Author :
Todorova, M. ; Stücklin, Ph ; Bertsch, A. ; Rohr, S. ; Renaud, Ph
Author_Institution :
Microsystems Lab., Lausanne
Abstract :
Microcantilevers on polysilicon were manufactured and living cardiomyocytes cells from neonatal rat hearts were cultured on top of them. The cells self-organize and start to contract after three days incubation. Moving the beams on which they are attached allows the measurement of the contractile force exerted by the cardiomyocytes. With this simple setup, the evaluation of the mechanical response of the cells due to changes in medium composition or temperature can be performed.
Keywords :
biomechanics; biomedical measurement; cantilevers; cardiology; cellular biophysics; force measurement; micromechanical devices; silicon; cardiomyocytes contraction; contractile force measurement; contraction measurements; living cardiomyocytes cells; mechanical response; microcantilevers; neonatal rat hearts; polysilicon; silicon cantilevers; three-day incubation; Cardiology; Cells (biology); Contracts; Force measurement; Heart; Manufacturing; Pediatrics; Performance evaluation; Silicon; Temperature; cardiomyocyte contraction; mechanical response; silicon cantilevers;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International
Conference_Location :
Lyon
Print_ISBN :
1-4244-0842-3
Electronic_ISBN :
1-4244-0842-3
DOI :
10.1109/SENSOR.2007.4300061
