Title :
Lactate dynamics during circulatory hypoxia. Mathematical model and analysis
Author :
Cabrera, Marco E. ; Saidel, Gerald M. ; Kalhan, Satish C.
Author_Institution :
Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA
Abstract :
The mechanistic basis of the relationship between O2 and lactate (LA) concentration in muscle are not fully understood. Increases in LA are frequently observed under hypoxic conditions and during high intensity exercise. However, there are other instances in which lactate can accumulate for reasons other than O2 limitation. Our aim is to investigate, using a mathematical model and computer simulations, potential regulatory mechanisms affecting the dynamics of LA in various tissues during hypoxic conditions. Simulations of circulatory hypoxia closely predicted the pattern of change in substrates observed experimentally. Model analysis suggests that the rate of lactate production is regulated with high sensitivity through changes in ADP/ATP and NADH/NAD which are induced indirectly by a small drop in the rate of oxygen consumption due to a decrease in muscle O2 concentration
Keywords :
biochemistry; cellular biophysics; haemodynamics; haemorheology; muscle; physiological models; ADP/ATP changes; NADH/NAD changes; O2 limitation; biochemical reactions; blood lactate; cellular metabolic processes; circulatory hypoxia; computer simulations; dynamic mass balances; human bioenergetic system; lactate dynamics; lactate production rate; mathematical model; muscle O2 concentration; potential regulatory mechanisms; tissue perfusion; Biomedical engineering; Blood; Computational modeling; Computer simulation; Humans; Joining processes; Mathematical model; Muscles; Predictive models; Production;
Conference_Titel :
Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
Print_ISBN :
0-7803-4262-3
DOI :
10.1109/IEMBS.1997.758749
