Lung ventilatory performance pressure-volume model, and parametric simulation for disease detection

Evaluation of lung ventilatory capability is carried out by evaluating lung volume capacities. However, lung ventilatory performance can be more intrinsically assessed in terms of lung compliance and airways resistance. For this purpose, the lung ventilatory model is developed in the form of the differential equation of lung volume (V) response to driving pressure (P_L)=atmospheric pressure-pleural pressure), in terms of lung compliance (C) and airway resistance (R). By making the solution of V in terms of P_L simulate patient data of cyclic variations of P_L(t) and V(t), we can evaluate C and R. By determining C and R parametric ranges for lung diseases, we can employ the model to detect lung diseases