Title :
In-Droplet Magnetic Beads Concentration and Separation for Digital Microfluidics
Author :
Wang, Yi Zhong ; Zhao, Yuejun ; Cho, Sung Kwon
Author_Institution :
Univ. of Pittsburgh, Pittsburgh
Abstract :
This paper describes highly efficient in-droplet particle concentrations/separations (over 91% in efficiency), where magnetic particles are concentrated/separated within a droplet by applying a magnetic field and a subsequent EWOD (electro wetting-on-dielectric) actuation physically splits a magnetic particle-rich region into an individual droplet. This in-droplet method will provide a new functionality of separation/concentration for digital (droplet-based) microfluidics, possibly allowing use of many magnetic-particles-based bio assays in digital microfluidics.
Keywords :
bioMEMS; drops; electromagnets; magnetic particles; magnetic separation; microfluidics; bio assays; digital microfluidics; droplet-based microfluidics; electro wetting-on-dielectric actuation; in-droplet magnetic bead concentration; in-droplet magnetic bead separation; magnetic particle-rich region; magnetic particles; Electrokinetics; Immune system; Magnetic fields; Magnetic particles; Magnetic separation; Mechanical engineering; Microchannel; Microfluidics; Permanent magnets; Surface resistance; Concentration; EWOD; Magnetic Beads; Separation;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International
Conference_Location :
Lyon
Print_ISBN :
1-4244-0842-3
Electronic_ISBN :
1-4244-0842-3
DOI :
10.1109/SENSOR.2007.4300229
