Automated Fluidic System with a Chaotic Microfluidic Reaction Chamber for Rapid, Multi-Analyte Immunosensing

Author

Kai, Junhai ; Zou, Zhiwei ; Han, Jungyoup ; Lee, Soo-Hyun ; Hong, Bin ; Ren, Yongjie ; Kang, Kyung A. ; Ahn, Chong H.

Author_Institution

Univ. of Cincinnati, Cincinnati

fYear

2007

fDate

10-14 June 2007

Firstpage

735

Lastpage

738

Abstract

In this paper, a fully automated fluidic system with a chaotic reaction chamber for rapid and accurate fiber-optic immuno-sensing has been developed and applied for the measurement of cardiac biomarkers. A new microchannel with serpentine bump structures has improved the sensor performance by generating local turbulence near the sensor surface. A full immunoassay with the automated fluidic system has been successfully performed, and the total assay time spent for detecting four cardiac markers was less than 10 minutes.

Keywords

bioMEMS; biosensors; fibre optic sensors; microchannel flow; automated fluidic system; cardiac biomarkers; chaotic microfluidic reaction chamber; fiber-optic immunosensor; immunoassay; microchannel; multianalyte immunosensing; serpentine bump structures; Chaos; Microfluidics; Cardiac Biomarkers; Chaotic Microfluidic; Fiber-Optic Immunosensor; Immunoassay;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International

Conference_Location

Lyon

Print_ISBN

1-4244-0842-3

Electronic_ISBN

1-4244-0842-3

Type

conf

DOI

10.1109/SENSOR.2007.4300235

Filename

4300235