Title :
A study of effect of some drugs on the free-radicals processes in vitro
Author :
Hadjimitova, V. ; Traykov, T. ; Goliysky, V. ; Karabacheva, Sv ; Ribarov, St
Author_Institution :
Med. Univ., Sofia, Bulgaria
Abstract :
Summary form only given. The search for new antioxidant agents is very important for the prevention and treatment of many chronic and degenerative diseases. The purpose of this study is to investigate the antioxidant activity of some drugs: Chloropromazine, Promethazine, Captopril, Cimetidine. The study was performed on a model lipid system at concentrations of 0.1-100 μmol/l. The results from TBA-test show that the phenothiazine derivatives have an antioxidant effect more pronounced than Cimetidine and Captopril. These results correlated well with the inhibition of Fe2+-induced chemiluminescence at the same model system. The chemiluminescent and photometric (NBT-test) registration of superoxide radicals generated in the system xantine-xantine oxydase indicates that the phenotiazine derivatives are good scavengers which partially explains their strong antioxidant properties
Keywords :
biochemistry; biological techniques; chemiluminescence; free radicals; medicine; patient treatment; photometry; Captopril; Chloropromazine; Cimetidine; Fe; Fe2+-induced chemiluminescence; Promethazine; TBA-test; antioxidant activity; antioxidant agents; disease prevention; disease treatment; in vitro free-radicals processes; model lipid system; phenothiazine derivatives; photometric registration; superoxide radicals; xantine-xantine oxydase system; Biophysics; Degenerative diseases; Drugs; In vitro; Lipidomics; Medical treatment; Photometry; Physics;
Conference_Titel :
Applied Electromagnetism, 2000. Proceedings of the Second International Symposium of Trans Black Sea Region on
Conference_Location :
Xanthi
Print_ISBN :
0-7803-6428-7
DOI :
10.1109/AEM.2000.943193
