A MEMS Based Optical Moire Approach for in Situ Cardiac Myocyte Force Probing

This paper presents, for the first time, a MEMS based optical moire technique for cardiac myocyte cellular force in situ probing. This platform can be used to generate flexible moire pattern that reflects the deformation of substrate consisting of micro polymer pillar matrix, which indicated the displacement and force distribution of the corresponding isolated cardiac myocyte. The magnification effect of optical moire made a high sensitivity measurement far beyond the capability of conventional measurement approaches, especially when the dimension of micro pillars becomes smaller and smaller and a higher sensitive in situ sensing method is desired.