Liquid-Phase Biochemical Sensing with Disk-Type Resonant Microsensor

Author

Seo, Jae H. ; Betancor, Lorena ; Demirci, Kemal S. ; Byun, Albert ; Spain, Jim ; Brand, Oliver

Author_Institution

Georgia Inst. of Technol., Atlanta

fYear

2007

fDate

10-14 June 2007

Firstpage

1737

Lastpage

1740

Abstract

The application of a resonant microsensor platform based on disk-type microstructures vibrating in an in-plane resonance mode for biochemical sensing in liquid environment is described. Based on the measured short-term frequency stabilities of 1.1 10^-8 in air and 2.3 10^-6 in water, low femtogram and sub-picogram detection limits can be achieved in air and in liquid, respectively. The feasibility of liquid-phase biosensing using the disk resonators is demonstrated experimentally by detecting anti-beta-galactosidase antibody using covalently immobilized beta-galactosidase enzyme.

Keywords

biochemistry; chemical sensors; microsensors; anti-beta-galactosidase antibody; disk-type resonant microsensor; frequency stabilities; liquid-phase biochemical sensing; liquid-phase biosensing; Biochemistry; Biosensors; Chemical and biological sensors; Frequency measurement; Mechanical sensors; Microsensors; Microstructure; Resonance; Resonant frequency; Stability; Biosensor; Mass-sensitive sensor; Resonant sensor; Ã\x9f-galactosidase enzyme;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International

Conference_Location

Lyon

Print_ISBN

1-4244-0842-3

Electronic_ISBN

1-4244-0842-3

Type

conf

DOI

10.1109/SENSOR.2007.4300488

Filename

4300488