Title :
Micro-Dissecting Dual-Probe Testicular Tubule Assay
Author :
Ramkumar, A. ; Chen, X. ; Paduch, D.A. ; Schlegel, P.N. ; Lai, Andy
Author_Institution :
Cornell Univ., Ithaca
Abstract :
We report on a microfabricated silicon probe integrated with an ultrasonic actuator and polysilicon strain gauges for Microdissection TEsticular Sperm Extraction (TESE) surgery. Insertion experiment was performed on rat testis tissue and by sensing the strain we were able to ascertain the size of the sperm-carrying microtubules in the sample. This information is important in Microdissection TESE to distinguish tubules with and without fertile sperm, eliminating large incision currently required for optical spermatazoa localization. Experimental data on tissue rigidity measurements indicate that the micromechanical assay can also be used for minimally-invasive testicular cancer detection.
Keywords :
bioMEMS; biological techniques; biological tissues; biosensors; cancer; strain gauges; TESE; dual-probe testicular tubule assay; microdissection testicular sperm extraction; optical spermatazoa localization; polysilicon strain gauges; rat testis tissue; testicular cancer detection; tissue rigidity measurement; ultrasonic actuator; Actuators; Biomedical optical imaging; Capacitive sensors; Data mining; Optical sensors; Performance evaluation; Probes; Silicon; Surgery; Testing; micro-probe; seminiferous tubules; strain gauge; testicle;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International
Conference_Location :
Lyon
Print_ISBN :
1-4244-0842-3
Electronic_ISBN :
1-4244-0842-3
DOI :
10.1109/SENSOR.2007.4300544
