Title :
High sensitivity potentiostat system for sub-micron bio-sensors impedance measurements
Author :
Carminati, Marco ; Ferrari, Giorgio ; Sampietro, Marco
Author_Institution :
Dipt. di Elettron. e Inf., Politec. di Milano, Milano
fDate :
Aug. 31 2008-Sept. 3 2008
Abstract :
The design and experimental characterization of a potentiostat system based on a novel modular architecture are illustrated. This instrument enables three amperometric measurements in liquid (cyclic voltammetry, electrochemical impedance spectroscopy and impedance tracking in time domain) on interfacial systems whose dimensions can range from the millimeter down to the sub-micrometric scale. In particular the system is aimed at the realization of biosensors based on the impedimetric detection of conformational changes of macromolecular biochemical transducers. To achieve high resolution (attoFarad in capacitance and TeraOhm in resistance) over a wide bandwidth (DC - 1 MHz) an integrator/differentiator front-end has been designed along with all the analog circuitry and software for numerical processing of acquired data.
Keywords :
biomedical transducers; biosensors; electric impedance measurement; electrochemical impedance spectroscopy; microsensors; voltammetry (chemical analysis); amperometric measurements; bio-sensors; cyclic voltammetry; electrochemical impedance spectroscopy; high sensitivity potentiostat system; impedance measurements; impedance tracking; macromolecular biochemical transducers; time domain; Bandwidth; Biosensors; Capacitance; Chemical transducers; Circuits; Electrochemical impedance spectroscopy; Immune system; Impedance measurement; Instruments; Time measurement;
Conference_Titel :
Electronics, Circuits and Systems, 2008. ICECS 2008. 15th IEEE International Conference on
Conference_Location :
St. Julien´s
Print_ISBN :
978-1-4244-2181-7
Electronic_ISBN :
978-1-4244-2182-4
DOI :
10.1109/ICECS.2008.4674962
