DocumentCode :
3390303
Title :
An experimental model investigation of pulmonary airway reopening
Author :
Perun, Matthew L. ; Gaver, Donald P.
Author_Institution :
Dept. of Biomed. Eng., Tulane Univ., New Orleans, LA, USA
fYear :
1993
fDate :
1993
Firstpage :
75
Lastpage :
77
Abstract :
Pulmonary airways are fluid lined compliant tubes that are supported by the surrounding parenchymal tissue. In certain diseased states such as emphysema, cystic fibrosis, adult and neonatal respiratory distress syndrome, airways become blocked either by the formation of a liquid meniscus bridge or by the collapse of the airway walls and surrounding parenchyma. The authors designed a benchtop model to mimic the second type of closure by using a collapsed untethered polyethylene tube lined with a Newtonian fluid acting as a viscous adhesive. Downstream of the air-liquid interface (meniscus), the tube was collapsed in a ribbon-like manner, while upstream of the meniscus the tube was constrained to a rectangular cross-section by two sheets of Plexi-glas separated by a distance D. The authors examined how the fluid properties (viscosity, mu , surface tension, gamma , and density, rho ) and the structural characteristics of their model (effective diameter, D, longitudinal tension, T, and fluid film thickness, H) affected the opening of the tube. D, T, and H corresponded to relevant physical conditions in the lung.
Keywords :
biorheology; lung; Newtonian fluid; air-liquid interface; airway walls collapse; benchtop model; collapsed untethered polyethylene tube; cystic fibrosis; density; emphysema; fluid lined compliant tubes; fluid properties; longitudinal tension; lung physical conditions; parenchyma; pulmonary airway reopening; respiratory distress syndrome; surface tension; viscosity; Biomedical engineering; Bridges; Pediatrics; Pistons; Polyethylene; Pressure measurement; Steady-state; Surface tension; Velocity measurement; Viscosity;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biomedical Engineering Conference, 1993., Proceedings of the Twelfth Southern
Conference_Location :
New Orleans, LA, USA
Print_ISBN :
0-7803-0976-6
Type :
conf
DOI :
10.1109/SBEC.1993.247344
Filename :
247344
Link To Document :
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