Title :
A biomechanical evaluation of RS-Ketoprofen and PGE2 treatment in reducing bone loss in ovariectomized rats
Author :
Saha, S. ; Bridges, L.W. ; Wechter, W.J.
Author_Institution :
Dept. of Orthopaedic Surg., Loma Linda Univ. Sch. of Med., CA, USA
Abstract :
Osteoporosis is the most common bone disorder in the USA. The authors evaluated the effectiveness of two experimental drugs, an arylpropionic acid (RS-Ketoprofen) and prostoglandin E2 (PGE2) in reducing the bone loss due to osteoporosis. Results of mechanical testing of long bones of ovariectomized rats of control groups and those treated with these drugs showed that a combination of these two drugs could be effective in reducing bone loss due to estrogen deficiency and maintain the mechanical integrity of the skeletal system.
Keywords :
biomechanics; bone; patient treatment; PGE2 treatment; RS-Ketoprofen; arylpropionic acid; biomechanical evaluation; bone disorder; bone loss reduction; estrogen deficiency; experimental drugs; long bone mechanical testing; osteoporosis; ovariectomized rats; prostoglandin E2; skeletal system mechanical integrity maintenance; Absorption; Animals; Bones; Bridges; Drugs; Medical treatment; Orthopedic surgery; Osteoporosis; Rats; Testing;
Conference_Titel :
Biomedical Engineering Conference, 1993., Proceedings of the Twelfth Southern
Conference_Location :
New Orleans, LA, USA
Print_ISBN :
0-7803-0976-6
DOI :
10.1109/SBEC.1993.247424
