Title :
Steady-state analysis of genetic regulatory networks modeled by nonlinear ordinary differential equations
Author :
Wang, Haixin ; Qian, Lijun ; Dougherty, Edward R.
Author_Institution :
Dept. of Math. & Comput. Sci., Fort Valley State Univ., Fort Valley, GA
fDate :
March 30 2009-April 2 2009
Abstract :
Although Ordinary Differential Equations (ODEs) have been used to model Genetic Regulatory Networks (GRNs) in many previous works, their steady-state behaviors are not well studied. However, a phenotype corresponds to a steady-state gene expression pattern and steady-state analysis of GRNs can provide valuable information on the stability of the GRNs, insights into cellular regulatory mechanisms underlying disease development as well as possible interventions for disease control. In this study, the steady-state behaviors of the nonlinear GRN models are analyzed based on time series data. The steady-state solutions and stability of nonlinear GRNs including polynomial model, sigmoidal model and S-system model are discussed in details.
Keywords :
cellular biophysics; diseases; genetics; molecular biophysics; nonlinear differential equations; S-system model; cellular regulatory mechanisms; disease control; disease development; genetic regulatory networks; nonlinear ordinary differential equation; sigmoidal model; steady-state GRN analysis; steady-state gene expression pattern; Differential equations; Diseases; Gene expression; Genetics; Information analysis; Pattern analysis; Polynomials; Stability analysis; Steady-state; Time series analysis;
Conference_Titel :
Computational Intelligence in Bioinformatics and Computational Biology, 2009. CIBCB '09. IEEE Symposium on
Conference_Location :
Nashville, TN
Print_ISBN :
978-1-4244-2756-7
DOI :
10.1109/CIBCB.2009.4925726